Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.49 |
| ▸ | PAK4 | O96013 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | MARK3 | P27448 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28502521 | 0.88 | DYRK1A (0.64) | CDK8DYRK1AAXLPIK3CAPIK3CD | |
| Tert-Butyl Formate SCHEMBL28812234 | 0.80 | PAK1 (0.48) | DYRK1APAK4PAK1METPDPK1 | |
| SCHEMBL28812233 | 0.79 | DYRK1A (0.53) | CDK8DYRK1APIK3CAPAK4JAK2 | |
| SCHEMBL15562746 | 0.78 | DYRK1A (0.52) | CDK8DYRK1APIK3CAFGFR1KDR | |
| SCHEMBL295510 | 0.78 | MAPK1 (0.59) | CDK8DYRK1AAXLPIK3CAPIK3CD | |
| SCHEMBL4831501 | 0.75 | CDK8 (0.81) | CDK8DYRK1AAXLPIK3CAPIK3CD | |
| SCHEMBL3377812 | 0.73 | JAK2 (0.57) | CDK8DYRK1APAK4JAK2ROCK2 | |
| SCHEMBL3375420 | 0.73 | AURKB (0.64) | CDK8DYRK1APAK4JAK2PRKD3 | |
| SCHEMBL3376133 | 0.72 | JAK2 (0.56) | CDK8DYRK1APAK4JAK2ROCK2 | |
| SCHEMBL29541367 | 0.72 | AURKB (0.63) | CDK8DYRK1APAK4JAK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024424-A | Pyrrolopyridine derivative, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2023-11-10 | — | — | CN | disclosed |