Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 12/20 | 0.76 |
| ▸ | CDK14 | O94921 | 3/20 | 0.36 |
| ▸ | CCNY | Q8ND76 | 3/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16117838 | 1.00 | KRAS (0.76) | KRASCDK14CCNYEGLN1ERBB2 | |
| SCHEMBL16117744 | 0.92 | KRAS (0.86) | KRASCDK14CCNYEGLN1ERBB2 | |
| SCHEMBL31672361 | 0.89 | KRAS (0.74) | KRASEGLN1ERBB2 | |
| SCHEMBL16117835 | 0.89 | KRAS (0.74) | KRASEGLN1ERBB2 | |
| SCHEMBL16117832 | 0.88 | KRAS (0.83) | KRASCDK14CCNYEGLN1ERBB2 | |
| SCHEMBL31672393 | 0.88 | KRAS (0.83) | KRASCDK14CCNYEGLN1ERBB2 | |
| SCHEMBL16122355 | 0.88 | KRAS (0.58) | KRASERBB2 | |
| SCHEMBL16117839 | 0.88 | KRAS (0.72) | KRASEGLN1ERBB2SCD | |
| SCHEMBL31672346 | 0.88 | KRAS (0.72) | KRASEGLN1ERBB2SCD | |
| SCHEMBL15337917 | 0.87 | KRAS (1.00) | KRASCDK14CCNYEGLN1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50527-E1 | Covalent inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2025-08-12 | — | — | US | disclosed |
| EP-3401314-B1 | COVALENT INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2023-11-08 | — | — | EP | disclosed |