Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24723083 | 0.88 | ALDH1A1 (0.44) | ALDH1A1CYP3A4TDP1TSHRCYP1A2 | |
| SCHEMBL1684411 | 0.82 | ALDH1A1 (0.48) | ALDH1A1CYP3A4TDP1TSHRCYP1A2 | |
| SCHEMBL2174996 | 0.81 | ALDH1A1 (0.56) | ALDH1A1CYP3A4TDP1TSHRCYP1A2 | |
| SCHEMBL9416708 | 0.80 | GPR35 (0.51) | ALDH1A1TDP1TSHRCYP1A2POLB | |
| SCHEMBL13159490 | 0.80 | ALDH1A1 (0.47) | ALDH1A1CYP3A4TDP1TSHRCYP1A2 | |
| SCHEMBL12431422 | 0.80 | HSD17B10 (0.55) | ALDH1A1CYP3A4TDP1TSHRCYP1A2 | |
| SCHEMBL2173166 | 0.79 | ALDH1A1 (0.58) | ALDH1A1CYP3A4TDP1TSHRCYP1A2 | |
| SCHEMBL30468473 | 0.79 | CYP1A2 (0.45) | ALDH1A1CYP3A4TDP1TSHRCYP1A2 | |
| SCHEMBL3379806 | 0.79 | CYP1A2 (0.45) | ALDH1A1CYP3A4TDP1TSHRCYP1A2 | |
| SCHEMBL4532457 | 0.78 | ALDH1A1 (0.55) | ALDH1A1CYP3A4TDP1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519267-A1 | HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BeiGene, Ltd. (KY) | 2025-03-12 | — | — | EP | disclosed |
| US-20250066372-A1 | HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BEIGENE, LTD. (KY) | 2025-02-27 | — | — | US | disclosed |
| CN-119156389-A | Heterocyclic compounds, compositions thereof and methods of treatment thereof | 百济神州有限公司 | 2024-12-17 | — | — | CN | disclosed |
| WO-2023213271-A1 | HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BEIGENE , LTD. (KY) | 2023-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066372-A1 | HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CDK1, CDK2, CDK4 | ALDH1A1 3122/4885CYP3A4 1602/4885TDP1 1136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.