Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13138797 | 0.82 | KCNA5 (0.39) | KCNA5KCNH2S1PR1VNN1LRRK2 | |
| SCHEMBL3075742 | 0.82 | SMN1; SMN2 (0.43) | KCNA5KCNH2CYP19A1VNN1GRM4 | |
| SCHEMBL3062558 | 0.79 | SMN1; SMN2 (0.51) | KCNA5KCNH2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL3074853 | 0.79 | VNN1 (0.38) | KCNA5KCNH2CYP19A1VNN1GRM4 | |
| SCHEMBL13138814 | 0.77 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL9197340 | 0.76 | SMN1; SMN2 (0.57) | KCNA5KCNH2CYP19A1VNN1LMNA | |
| SCHEMBL4380408 | 0.76 | CYP19A1 (0.42) | KCNA5CYP19A1VNN1GRM5GRM4 | |
| SCHEMBL3065142 | 0.73 | SLC22A12 (0.49) | KCNA5KCNH2GRM5SLC22A12CHRNB2 | |
| SCHEMBL3059643 | 0.71 | KCNA5 (0.49) | KCNA5KCNH2GRM5SMN1; SMN2SLC22A12 | |
| SCHEMBL3064453 | 0.70 | KCNA5 (0.53) | KCNA5KCNH2GRM5SLC22A12CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128431-B | Novel quinoline derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA NV | 2011-05-25 | — | — | CN | disclosed |
| US-7790895-B2 | Quinoline derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-07 | — | — | US | disclosed |
| US-7790895-B2 | Quinoline derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-07 | — | — | US | disclosed |
| US-7790895-B2 | Quinoline derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-07 | — | — | US | disclosed |
| US-7671065-B2 | Pyridine derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-03-02 | — | — | US | disclosed |
| US-7671065-B2 | Pyridine derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-03-02 | — | — | US | disclosed |
| US-7671065-B2 | Pyridine derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-03-02 | — | — | US | disclosed |
| CN-101128431-A | Novel quinoline derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-20 | — | — | CN | disclosed |
| CN-101128428-A | Pyridine derivatives as potassium channel openers | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-20 | — | — | CN | disclosed |
| EP-1858853-A2 | NOVEL PYRIDINE DERIVATIVES AS POTASSIUM ION CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-28 | — | — | EP | disclosed |
| EP-1853564-A1 | NOVEL QUINOLINE DERIVATIVES AS POTASSIUM ION CHANNEL OPENERS | Janssen Pharmaceutica N.V. (BE) | 2007-11-14 | — | — | EP | disclosed |
| US-20070054936-A1 | Novel quinoline derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-08 | — | — | US | disclosed |
| US-20070054936-A1 | Novel quinoline derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-08 | — | — | US | disclosed |
| US-20070054936-A1 | Novel quinoline derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-08 | — | — | US | disclosed |
| US-20070054935-A1 | Novel pyridine derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-08 | — | — | US | disclosed |
| US-20070054935-A1 | Novel pyridine derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-08 | — | — | US | disclosed |
| US-20070054935-A1 | Novel pyridine derivatives as potassium ion channel openers | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-08 | — | — | US | disclosed |
| WO-2006091769-A1 | NOVEL QUINOLINE DERIVATIVES AS POTASSIUM ION CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-08-31 | — | — | WO | disclosed |
| WO-2006091800-A2 | NOVEL PYRIDINE DERIVATIVES AS POTASSIUM ION CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054936-A1 | Novel quinoline derivatives as potassium ion channel openers | KCNQ1, KCNQ2, KCNJ2 | KCNA5 25/4885KCNH2 11/4885CYP19A1 3995/4885 |
| US-20070054935-A1 | Novel pyridine derivatives as potassium ion channel openers | KCNJ2, KCNQ2, KCNQ1 | KCNA5 27/4885KCNH2 11/4885CYP19A1 3874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.