Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | CTSD | P07339 | 2/20 | 0.41 |
| ▸ | CTSE | P14091 | 2/20 | 0.41 |
| ▸ | PGC | P20142 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073914 | 0.90 | REN (0.44) | RENCTSDCTSEPGC | |
| SCHEMBL3084349 | 0.90 | REN (0.42) | RENCTSDCTSEPGCNPC1 | |
| SCHEMBL3083589 | 0.90 | REN (0.55) | RENCTSDCTSEPGC | |
| SCHEMBL8263496 | 0.87 | REN (0.57) | RENALOX5CTSDCTSEPGC | |
| SCHEMBL2938316 | 0.79 | REN (0.39) | RENCTSDCTSEPGCMRGPRX4 | |
| SCHEMBL2934499 | 0.79 | REN (0.49) | RENCTSDCTSEPGCMRGPRX4 | |
| SCHEMBL3070444 | 0.79 | REN (0.51) | RENCTSDCTSEPGC | |
| SCHEMBL13177123 | 0.77 | REN (0.56) | RENALOX5CTSDCTSEPGC | |
| SCHEMBL13404514 | 0.76 | REN (0.53) | RENALOX5CTSDCTSEPGC | |
| SCHEMBL13404512 | 0.74 | REN (0.65) | RENCTSDCTSEPGC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | claimed |