Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | SOD1 | P00441 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982393 | 0.83 | ALDH1A1 (0.46) | AKR1B1KDM4EKMT2AMEN1SOD1 | |
| SCHEMBL11206055 | 0.81 | APEX1 (0.48) | FFAR1AKR1B1KDM4EKMT2AMEN1 | |
| SCHEMBL3979840 | 0.81 | ALDH1A1 (0.48) | AKR1B1KMT2AMEN1SOD1ALDH1A1 | |
| SCHEMBL6243529 | 0.80 | CYP1A2 (0.53) | FFAR1AKR1B1KDM4EKMT2AMEN1 | |
| SCHEMBL29812491 | 0.79 | CYP1A2 (0.61) | FFAR1AKR1B1KDM4EKMT2AMEN1 | |
| SCHEMBL1157659 | 0.79 | CYP1A2 (0.61) | FFAR1AKR1B1KDM4EKMT2AMEN1 | |
| SCHEMBL3454803 | 0.77 | ALDH1A1 (0.51) | AKR1B1KMT2AMEN1SOD1ALDH1A1 | |
| SCHEMBL351155 | 0.77 | CYP1A2 (0.50) | FFAR1AKR1B1KDM4EKMT2AMEN1 | |
| SCHEMBL11264770 | 0.77 | APEX1 (0.44) | AKR1B1KDM4EKMT2AMEN1APEX1 | |
| SCHEMBL3070296 | 0.76 | POLB (0.62) | FFAR1AKR1B1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083799-B | Benzimidazole derivatives used as FXR agonists | HOFFMANN LA ROCHE | 2013-10-16 | — | — | CN | disclosed |
| EP-2188263-B1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-102083799-A | Benzimidazole derivatives used as FXR agonists | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| US-7790904-B2 | Substituted benzimidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-2188263-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. Hoffmann-Roche AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| US-20090062356-A1 | SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2009-03-05 | — | — | US | disclosed |
| WO-2009027264-A1 | BENZIMIDAZOLE DERIVATIVES USED AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-03-05 | — | — | WO | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| US-6080768-A | USEFUL IN THE TREATMENT OF ARTERIAL HYPERTENSION AND HEART FAILURE, RENAL INSUFFICIENCY, PERIPHERAL ARTERIOPATHIES AND CEREBROVASCULAR INSUFFICIENCIES | ZAMBON GROUP S.P.A. (IT) | 2000-06-27 | — | — | US | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
| EP-0719252-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 1998-02-18 | — | — | EP | disclosed |
| EP-0719252-A1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995007885-A1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.P.A. (IT) | 1995-03-23 | — | — | WO | disclosed |
| US-4892952-A | Substituted heteroaralkyl, heteroaralkenyl or halomethyl fungicides | CHEVRON RESEARCH COMPANY (US) | 1990-01-09 | — | — | US | disclosed |
| US-4782074-A | Fungicidal N,N-disubstituted-heterocyclic carboxamides | CHEVRON RESEARCH COMPANY (US) | 1988-11-01 | — | — | US | disclosed |
| US-4672065-A | TOMATO LATE BLIGHT | CHEVRON RESEARCH COMPANY (US) | 1987-06-09 | — | — | US | disclosed |
| US-4654346-A | Fungicidal N,N-disubstituted-heterocyclic carboxamides | CHEVRON RESEARCH COMPANY (US) | 1987-03-31 | — | — | US | disclosed |
| US-4588735-A | Fungicidal (trihalophenoxy or trihalophenthio) alkylaminoalkyl pyridines and pyrroles | CHEVRON RESEARCH COMPANY (US) | 1986-05-13 | — | — | US | disclosed |
| US-4535087-A | FOR TOMATO LATE BLIGHT | CHEVRON RESEARCH COMPANY (US) | 1985-08-13 | — | — | US | disclosed |
| US-4504484-A | Certain N,N-di-substituted-pyridine carboxamides, fungicidal compositions and fungicidal method of use | CHEVRON RESEARCH COMPANY (US) | 1985-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062356-A1 | SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NR1H4, SLC10A1, FXR1 | FFAR1 84/4885AKR1B1 1073/4885KDM4E 3353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.