Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 7/20 | 0.54 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1843397 | 1.00 | MGMT (0.54) | MGMTPIN1MEN1KMT2ANPC1 | |
| SCHEMBL14027831 | 0.83 | MGMT (0.54) | MGMTPIN1MEN1KMT2ANPC1 | |
| SCHEMBL3591208 | 0.83 | MGMT (0.54) | MGMTPIN1MEN1KMT2ANPC1 | |
| SCHEMBL8564287 | 0.83 | MGMT (0.61) | MGMTPIN1MEN1KMT2ANPC1 | |
| SCHEMBL1840400 | 0.82 | MGMT (0.53) | MGMTPIN1MEN1KMT2ANPC1 | |
| SCHEMBL6082323 | 0.81 | PIN1 (0.46) | MGMTPIN1MEN1KMT2ANPC1 | |
| SCHEMBL26640374 | 0.80 | MGMT (0.51) | MGMTPIN1MEN1KMT2ANPC1 | |
| SCHEMBL3586604 | 0.80 | MGMT (0.51) | MGMTPIN1MEN1KMT2ANPC1 | |
| SCHEMBL26640090 | 0.79 | MGMT (0.50) | MGMTPIN1MEN1KMT2ANPC1 | |
| SCHEMBL6082553 | 0.78 | TLR8 (0.44) | MGMTPIN1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |