Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26640019 | 1.00 | NR1H2 (0.43) | NR1H2PDK2S1PR1HSD17B3NAMPT | |
| SCHEMBL17797497 | 0.79 | NR1H2 (0.38) | NR1H2PDK2S1PR1HSD17B3NAMPT | |
| SCHEMBL14067293 | 0.78 | PDK2 (0.43) | NR1H2PDK2S1PR1HSD17B3NAMPT | |
| SCHEMBL30885125 | 0.77 | ATAD2 (0.47) | NR1H2PDK2S1PR1HSD17B3NAMPT | |
| SCHEMBL1950828 | 0.76 | NR1H2 (0.49) | NR1H2HDAC8PRMT5WDR77 | |
| SCHEMBL27981478 | 0.76 | HSD17B3 (0.43) | NR1H2PDK2S1PR1HSD17B3NAMPT | |
| SCHEMBL6808725 | 0.75 | NR1H2 (0.45) | NR1H2PDK2S1PR1HSD17B3NAMPT | |
| SCHEMBL18491671 | 0.74 | NR1H2 (0.36) | NR1H2PDK2S1PR1HSD17B3NAMPT | |
| SCHEMBL26640284 | 0.74 | DPP7 (0.48) | NAMPTDPP7LMNAKDM4EMAPT | |
| SCHEMBL6070593 | 0.73 | NR1H2 (0.43) | NR1H2PDK2S1PR1HSD17B3NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |