Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30885125 | 0.82 | ATAD2 (0.47) | PDK2HSD17B3HDAC8NR1H2LMNA | |
| SCHEMBL27981478 | 0.81 | HSD17B3 (0.43) | PDK2HSD17B3HDAC8NR1H2LMNA | |
| SCHEMBL521423 | 0.80 | HDAC8 (0.44) | PDK2HSD17B3HDAC8NR1H2MAPT | |
| SCHEMBL26640019 | 0.78 | NR1H2 (0.43) | PDK2HSD17B3HDAC8NR1H2LMNA | |
| SCHEMBL30648706 | 0.78 | NR1H2 (0.43) | PDK2HSD17B3HDAC8NR1H2LMNA | |
| SCHEMBL17797497 | 0.77 | NR1H2 (0.38) | PDK2HSD17B3HDAC8NR1H2LMNA | |
| SCHEMBL21412709 | 0.77 | TERT (0.53) | PDK2MAPTALDH1A1RAB9AACHE | |
| SCHEMBL17797637 | 0.77 | PDK2 (0.36) | PDK2HSD17B3HDAC8NR1H2LMNA | |
| SCHEMBL1953020 | 0.77 | DRD2 (0.46) | HSD17B3HDAC8NR1H2 | |
| SCHEMBL1948812 | 0.77 | NR1H2 (0.45) | HDAC8NR1H2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325910-B1 | ALIPHATIC NITROGENOUS FIVE-MEMBERED RING COMPOUNDS | MITSUBISHI TANABE PHARMA CORP (JP) | 2008-09-17 | — | — | EP | disclosed |