Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 13/20 | 0.89 |
| ▸ | ABL1 | P00519 | 13/20 | 0.89 |
| ▸ | KIT | P10721 | 9/20 | 0.89 |
| ▸ | BCR | P11274 | 10/20 | 0.81 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.81 |
| ▸ | EGFR | P00533 | 2/20 | 0.79 |
| ▸ | PRKCA | P17252 | 1/20 | 0.79 |
| ▸ | KDR | P35968 | 2/20 | 0.76 |
| ▸ | PLK4 | O00444 | 1/20 | 0.76 |
| ▸ | DDX3X | O00571 | 1/20 | 0.76 |
| ▸ | GAK | O14976 | 1/20 | 0.76 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.76 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.76 |
| ▸ | CA12 | O43570 | 1/20 | 0.76 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | CA1 | P00915 | 1/20 | 0.76 |
| ▸ | CA2 | P00918 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | ALB | P02768 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3071844 | 0.95 | PDGFRA (0.80) | PDGFRAABL1KITBCRPDGFRB | |
| SCHEMBL723757 | 0.94 | PDGFRA (1.00) | PDGFRAABL1KITBCRPDGFRB | |
| Hydrochloric Acid SCHEMBL4396677 | 0.93 | PDGFRA (0.98) | PDGFRAABL1KITBCRPDGFRB | |
| SCHEMBL27804782 | 0.91 | PDGFRA (0.85) | PDGFRAABL1KITBCRPDGFRB | |
| SCHEMBL805395 | 0.91 | PDGFRA (0.85) | PDGFRAABL1KITBCRPDGFRB | |
| SCHEMBL25281830 | 0.90 | PDGFRA (1.00) | PDGFRAABL1KITBCRPDGFRB | |
| SCHEMBL14292529 | 0.90 | PDGFRA (0.84) | PDGFRAABL1KITBCRPDGFRB | |
| SCHEMBL29628979 | 0.90 | PDGFRA (1.00) | PDGFRAABL1KITBCRPDGFRB | |
| SCHEMBL21248036 | 0.90 | PDGFRA (0.84) | PDGFRAABL1KITBCRPDGFRB | |
| SCHEMBL11927813 | 0.90 | PDGFRA (1.00) | PDGFRAABL1KITBCRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130121963-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-20100221221-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130121963-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | NME2, NME1, ABL1 | PDGFRA 158/4885ABL1 3/4885KIT 1603/4885 |
| US-20100221221-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | NME2, NME1, ABL1 | PDGFRA 158/4885ABL1 3/4885KIT 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.