Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 5/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.36 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.36 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26654056 | 1.00 | SMARCA2 (0.38) | SMARCA2SMARCA4PBRM1CCNT1CDK9 | |
| SCHEMBL31505531 | 0.86 | CCNT1 (0.41) | SMARCA2SMARCA4PBRM1CCNT1CDK9 | |
| SCHEMBL30658056 | 0.86 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1BACE1BACE2 | |
| SCHEMBL26654036 | 0.86 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1BACE1BACE2 | |
| SCHEMBL31505584 | 0.79 | SMARCA2 (0.37) | SMARCA2SMARCA4PBRM1CCNT1CDK9 | |
| SCHEMBL26654126 | 0.79 | SMARCA2 (0.37) | SMARCA2SMARCA4PBRM1CCNT1CDK9 | |
| SCHEMBL25215923 | 0.79 | SMARCA2 (0.39) | SMARCA2SMARCA4PBRM1CCNT1CDK9 | |
| SCHEMBL26654083 | 0.77 | SMARCA2 (0.55) | SMARCA2SMARCA4PBRM1CCNKCDK12 | |
| SCHEMBL30658017 | 0.77 | SMARCA2 (0.55) | SMARCA2SMARCA4PBRM1CCNKCDK12 | |
| SCHEMBL31505633 | 0.76 | TACR1 (0.39) | SMARCA2SMARCA4PBRM1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522279-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |