Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 7/20 | 0.33 |
| ▸ | CDK2 | P24941 | 7/20 | 0.33 |
| ▸ | KDR | P35968 | 7/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26656440 | 1.00 | BRAF (0.36) | BRAFGAKPTGS1PTGS2CDK1 | |
| SCHEMBL30666120 | 1.00 | BRAF (0.36) | BRAFGAKPTGS1PTGS2CDK1 | |
| SCHEMBL26864188 | 1.00 | BRAF (0.36) | BRAFGAKPTGS1PTGS2CDK1 | |
| SCHEMBL26864929 | 0.90 | ALDH1A1 (0.35) | BRAFGAKPTGS1PTGS2CDK1 | |
| SCHEMBL26863549 | 0.90 | GAK (0.33) | GAKPTGS1PTGS2CDK1CDK2 | |
| SCHEMBL26863383 | 0.89 | PTGS1 (0.34) | GAKPTGS1PTGS2CDK1CDK2 | |
| SCHEMBL26863546 | 0.88 | BRAF (0.35) | BRAFALDH1A1MAPTMTNR1A | |
| SCHEMBL25465686 | 0.87 | HTR1A (0.47) | GAKHTTPDGFRAALDH1A1GAA | |
| SCHEMBL26863377 | 0.83 | GAK (0.39) | GAKPTGS1PTGS2KDRHTT | |
| SCHEMBL26862953 | 0.83 | IKBKB (0.38) | BRAFGAKPTGS1PTGS2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225001-A1 | NAPHTHYRIDINE BASED ENPP1 MODULATORS AND USES THEREOF | Vir Biotechnology, Inc. (US) | 2023-11-23 | — | — | WO | disclosed |