SCHEMBL30673111

SCHEMBL30673111

C=Cc1nn(C2CCCCO2)c2ccc(Br)cc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.36
MAPK1 P28482 2/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
RXRA P19793 1/20 0.35
RXRB P28702 1/20 0.35
RXRG P48443 1/20 0.35
RET P07949 2/20 0.33
CYP4F2 P78329 2/20 0.33
CYP4A11 Q02928 2/20 0.33
KRAS P01116 5/20 0.32
FLT3 P36888 2/20 0.31
ALOX15 P16050 1/20 0.31
CNR2 P34972 2/20 0.31
CDK1 P06493 2/20 0.30
CCNB2 O95067 1/20 0.30
CCNB1 P14635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26924742 1.00 MAPT (0.36) MAPTMAPK1ALDH1A1LMNATP53
SCHEMBL660435 0.89 ALDH1A1 (0.36) MAPTMAPK1ALDH1A1LMNATP53
SCHEMBL14493344 0.86 CYP4F2 (0.37) RXRARXRBRXRGRETCYP4F2
SCHEMBL30182911 0.84 MAPT (0.38) MAPTMAPK1ALDH1A1LMNATP53
SCHEMBL30786255 0.83 MAP3K5 (0.36) ALDH1A1LMNAHTTRXRARXRB
SCHEMBL24552691 0.82 RET (0.36) ALDH1A1LMNARXRARXRBRXRG
SCHEMBL29732489 0.82 RET (0.36) ALDH1A1LMNARXRARXRBRXRG
SCHEMBL18281904 0.81 GAA (0.41) MAPTMAPK1ALDH1A1LMNATP53
SCHEMBL15744178 0.81 CYP4F2 (0.39) MAPTMAPK1ALDH1A1LMNATP53
SCHEMBL9904367 0.81 MAPT (0.37) MAPTMAPK1ALDH1A1LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4536224-A1 INDAZOLE CONTAINING MACROCYCLES AND THEIR USE Blossomhill Therapeutics, Inc. (US) 2025-04-16 EP disclosed