Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 14/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30677012 | 0.88 | CRACR2A (0.55) | CRACR2AKLKB1ORAI1PTGS2 | |
| SCHEMBL31625043 | 0.88 | PTGS2 (0.48) | CRACR2AORAI1PTGS2CYP2C9 | |
| SCHEMBL30677116 | 0.80 | PDPK1 (0.47) | CRACR2AORAI1 | |
| SCHEMBL31625056 | 0.77 | CRACR2A (0.44) | CRACR2AKLKB1ORAI1 | |
| SCHEMBL4755012 | 0.76 | KLKB1 (0.50) | KLKB1ORAI1PTGS2CYP2C9 | |
| SCHEMBL30677026 | 0.75 | CRACR2A (0.40) | CRACR2AORAI1 | |
| SCHEMBL30785292 | 0.75 | CRACR2A (0.53) | CRACR2AORAI1PTGS2 | |
| SCHEMBL30785286 | 0.75 | CRACR2A (0.56) | CRACR2AORAI1PTGS2 | |
| SCHEMBL18865512 | 0.74 | KLKB1 (0.49) | KLKB1ORAI1PTGS2CYP2C9 | |
| SCHEMBL18865827 | 0.74 | KLKB1 (0.42) | KLKB1PTGS2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025129135-A2 | COMPOSITIONS COMPRISING USP1 INHIBITORS AND METHODS OF USING THE SAME | EIKON THERAPEUTICS, INC. (US) | 2025-06-19 | — | — | WO | disclosed |
| EP-4543890-A1 | USP1 INHIBITORS AND USES THEREOF | Forma Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| CN-119731178-A | USP1 inhibitors and uses thereof | 福马治疗有限公司 | 2025-03-28 | — | — | CN | disclosed |
| WO-2023250084-A1 | USP1 INHIBITORS AND USES THEREOF | FORMA THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |