Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501841 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1POLBTP53GLA | |
| SCHEMBL2169035 | 0.91 | KDM4E (0.52) | KDM4EALDH1A1POLBTP53GLA | |
| SCHEMBL14506392 | 0.91 | KDM4E (0.52) | KDM4EALDH1A1POLBTP53GLA | |
| SCHEMBL7850983 | 0.91 | MEN1 (0.38) | KDM4EALDH1A1POLBTP53GLA | |
| SCHEMBL15247750 | 0.89 | KDM4E (0.44) | KDM4EALDH1A1POLBTP53GLA | |
| SCHEMBL6368923 | 0.89 | KDM4E (0.37) | KDM4EALDH1A1POLBTP53GLA | |
| SCHEMBL2257304 | 0.88 | KDM4E (0.45) | KDM4EALDH1A1POLBTP53GLA | |
| SCHEMBL20425363 | 0.88 | KDM4E (0.45) | KDM4EALDH1A1POLBTP53GLA | |
| SCHEMBL2169082 | 0.88 | ALDH1A1 (0.40) | KDM4EALDH1A1POLBHSD17B10L3MBTL1 | |
| SCHEMBL18747986 | 0.87 | ALOX15 (0.36) | KDM4EALDH1A1POLBTP53GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4611798-A1 | METHODS OF TREATMENT WITH T CELL THERAPY AND IMMUNOMODULATORY AGENT MAINTENANCE THERAPY | CELGENE CORPORATION (US) | 2025-09-10 | — | — | EP | disclosed |
| EP-4543923-A1 | TREATMENT METHODS FOR SECOND LINE THERAPY OF CD19-TARGETED CAR T CELLS | Juno Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| CN-119546638-A | Therapeutic methods for two-line therapy of CD19 targeted CAR T cells | 朱诺治疗学股份有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-118948892-A | Combination of cell therapy with immunomodulatory compounds | 朱诺治疗学股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118662614-A | Articles and methods of treatment using adoptive cell therapy | 朱诺治疗学股份有限公司 | 2024-09-20 | — | — | CN | disclosed |
| WO-2024097905-A1 | METHODS OF TREATMENT WITH T CELL THERAPY AND IMMUNOMODULATORY AGENT MAINTENANCE THERAPY | CELGENE CORPORATION (US) | 2024-05-10 | — | — | WO | disclosed |
| CN-111225675-B | Articles and methods of treatment using adoptive cell therapy | 朱诺治疗学股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023250400-A1 | TREATMENT METHODS FOR SECOND LINE THERAPY OF CD19-TARGETED CAR T CELLS | JUNO THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |