Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 10/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13981656 | 0.89 | SIRT6 (0.73) | SIRT6MAPTTHRBPKML3MBTL1 | |
| SCHEMBL14852502 | 0.84 | SIRT6 (1.00) | SIRT6MAPTTHRBPKML3MBTL1 | |
| SCHEMBL4772717 | 0.83 | MAPT (0.72) | SIRT6MAPTL3MBTL1MAPK1LMNA | |
| SCHEMBL22652221 | 0.83 | L3MBTL1 (0.51) | SIRT6MAPTL3MBTL1MAPK1LMNA | |
| SCHEMBL4762192 | 0.83 | MAPT (0.57) | SIRT6MAPTL3MBTL1MAPK1LMNA | |
| SCHEMBL4723486 | 0.83 | L3MBTL1 (0.51) | SIRT6MAPTL3MBTL1MAPK1LMNA | |
| SCHEMBL26087649 | 0.83 | SIRT6 (0.56) | SIRT6MAPTL3MBTL1MAPK1LMNA | |
| SCHEMBL31296613 | 0.83 | SIRT6 (0.56) | SIRT6MAPTL3MBTL1MAPK1LMNA | |
| SCHEMBL14406631 | 0.82 | SIRT6 (0.67) | SIRT6MAPTTHRBPKML3MBTL1 | |
| SCHEMBL19899574 | 0.82 | MAPT (0.75) | SIRT6MAPTTHRBPKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116981664-A | Thienyl and cycloalkyl aminopyrimidine compounds as inhibitors of NUAK kinase, compositions and uses thereof | 安大略省癌症研究所(OICR) | 2023-10-31 | — | — | CN | disclosed |