Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD known ✓ | O00329 | 17/20 | 0.48 |
| ▸ | PIK3CG known ✓ | P48736 | 13/20 | 0.48 |
| ▸ | PIK3CB known ✓ | P42338 | 10/20 | 0.48 |
| ▸ | PIK3CA known ✓ | P42336 | 8/20 | 0.48 |
| ▸ | ABL1 known ✓ | P00519 | 5/20 | 0.43 |
| ▸ | EGFR known ✓ | P00533 | 5/20 | 0.43 |
| ▸ | KDR known ✓ | P35968 | 5/20 | 0.43 |
| ▸ | PIK3R1 known ✓ | P27986 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 5/20 | 0.43 |
| ▸ | SRC | P12931 | 5/20 | 0.43 |
| ▸ | MTOR | P42345 | 5/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.43 |
| ▸ | PRKDC | P78527 | 5/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22498171 | 1.00 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL22498167 | 1.00 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL22498197 | 0.97 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL22498067 | 0.97 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL29641606 | 0.97 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL22504983 | 0.97 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| SCHEMBL30679707 | 0.97 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| Hydrochloric Acid SCHEMBL22498347 | 0.97 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| Hydrochloric Acid SCHEMBL22498242 | 0.97 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 | |
| Hydrochloric Acid SCHEMBL29641518 | 0.97 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947384-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2023-11-01 | — | — | EP | claimed |
| EP-3947384-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2023-11-01 | — | — | EP | disclosed |