Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20669674 | 0.88 | AAK1 (0.44) | AAK1L3MBTL1KDM4AMAPKAPK2KDM4E | |
| SCHEMBL30683066 | 0.87 | AAK1 (0.39) | AAK1L3MBTL1NAMPTKDM4AMAPKAPK2 | |
| SCHEMBL26932161 | 0.84 | KDM4E (0.39) | RECQLKDM4ELMNA | |
| SCHEMBL30683085 | 0.83 | BRD4 (0.38) | AAK1BRD4L3MBTL1NAMPTKDM4A | |
| SCHEMBL30683043 | 0.81 | BRD4 (0.37) | BRD4L3MBTL1NAMPTKDM4AMAPKAPK2 | |
| SCHEMBL29918736 | 0.80 | AAK1 (0.51) | AAK1BRD4L3MBTL1NAMPTKDM4A | |
| SCHEMBL16814130 | 0.80 | AAK1 (0.51) | AAK1BRD4L3MBTL1NAMPTKDM4A | |
| SCHEMBL16809853 | 0.79 | AAK1 (0.45) | AAK1L3MBTL1NAMPTKDM4AMAPKAPK2 | |
| SCHEMBL2943289 | 0.79 | AAK1 (0.45) | AAK1L3MBTL1NAMPTKDM4AMAPKAPK2 | |
| SCHEMBL30162902 | 0.79 | AAK1 (0.45) | AAK1L3MBTL1NAMPTKDM4AMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |