Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26932080 | 1.00 | TSHR (0.42) | TSHRTP53HTTCYP1A2CYP2C9 | |
| SCHEMBL26932275 | 0.86 | TSHR (0.40) | TSHRTP53HTTCYP1A2CYP2C9 | |
| SCHEMBL30683104 | 0.83 | PTPN11 (0.37) | TSHRTP53HTTPTPRBALDH1A1 | |
| SCHEMBL30200680 | 0.83 | PTPN11 (0.37) | TSHRTP53HTTPTPRBALDH1A1 | |
| SCHEMBL25602514 | 0.83 | FAAH (0.40) | ALDH1A1CTSSCTSKACACBLMNA | |
| SCHEMBL17844760 | 0.83 | TSHR (0.48) | TSHRTP53HTTCYP1A2CYP2C9 | |
| SCHEMBL21458419 | 0.82 | MAPT (0.47) | TSHRTP53HTTCYP1A2CYP2C9 | |
| SCHEMBL21458417 | 0.82 | MAPT (0.47) | TSHRTP53HTTCYP1A2CYP2C9 | |
| SCHEMBL12733028 | 0.81 | SMN1; SMN2 (0.46) | TSHRPTPN1ALDH1A1ACACB | |
| SCHEMBL24838329 | 0.81 | CTSS (0.35) | TSHRTP53HTTALDH1A1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |