Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30200406 | 1.00 | CTSS (0.46) | CTSSCTSKAAK1MAPTALDH1A1 | |
| SCHEMBL34471964 | 0.92 | CTSS (0.43) | CTSSCTSKAAK1MAPTALDH1A1 | |
| SCHEMBL2634242 | 0.88 | MAPT (0.46) | CTSSCTSKAAK1MAPTALDH1A1 | |
| SCHEMBL29373349 | 0.88 | MAPT (0.46) | CTSSCTSKAAK1MAPTALDH1A1 | |
| SCHEMBL31628315 | 0.86 | CTSS (0.48) | CTSSCTSKAAK1MAPTALDH1A1 | |
| SCHEMBL15092632 | 0.86 | MAPT (0.48) | CTSSCTSKAAK1MAPTALDH1A1 | |
| SCHEMBL19312076 | 0.86 | CTSK (0.53) | CTSSCTSKMAPT | |
| SCHEMBL31017568 | 0.86 | MAPT (0.48) | CTSSCTSKAAK1MAPTALDH1A1 | |
| SCHEMBL13184597 | 0.86 | CTSK (0.53) | CTSSCTSKMAPT | |
| SCHEMBL19580945 | 0.86 | CTSS (0.48) | CTSSCTSKAAK1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |