Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CGAS | Q8N884 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | PAK4 | O96013 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | PRKX | P51817 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.33 |
| ▸ | STK3 | Q13188 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | MELK | Q14680 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26912963 | 1.00 | CGAS (0.36) | CGASCDC7DAPK3PRKD3PAK4 | |
| SCHEMBL26912165 | 1.00 | CGAS (0.36) | CGASCDC7DAPK3PRKD3PAK4 | |
| SCHEMBL26912169 | 1.00 | CGAS (0.36) | CGASCDC7DAPK3PRKD3PAK4 | |
| SCHEMBL26912514 | 0.93 | CGAS (0.36) | CGASJAK2JAK1ROCK2ROCK1 | |
| SCHEMBL26913132 | 0.93 | CGAS (0.36) | CGASJAK2JAK1ROCK2ROCK1 | |
| SCHEMBL26913152 | 0.84 | ROCK2 (0.34) | CGASCDK2CDK9JAK2JAK1 | |
| SCHEMBL26913150 | 0.84 | ROCK2 (0.34) | CGASCDK2CDK9JAK2JAK1 | |
| SCHEMBL26912028 | 0.83 | LRRK2 (0.37) | CGASJAK3JAK2JAK1AKT1 | |
| SCHEMBL30684099 | 0.81 | CGAS (0.37) | CGASPIK3CAROCK2ROCK1CDC42BPB | |
| SCHEMBL26912152 | 0.81 | CGAS (0.37) | CGASPIK3CAROCK2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023235809-A1 | CGAS INHIBITORS | ELI LILLY AND COMPANY (US) | 2023-12-07 | — | — | WO | disclosed |