Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2690664 | 0.82 | FFAR2 (0.53) | FFAR2KDRCCNE1CDK2 | |
| SCHEMBL15941111 | 0.82 | FFAR2 (0.45) | FFAR2SMN1; SMN2MAPK10ALDH1A1 | |
| SCHEMBL15940820 | 0.81 | CA12 (0.46) | FFAR2SMN1; SMN2MAPK10KMT2AALDH1A1 | |
| SCHEMBL6361249 | 0.77 | SMN1; SMN2 (0.61) | TP53SMN1; SMN2MEN1CYP1A2KMT2A | |
| SCHEMBL17353987 | 0.76 | SMN1; SMN2 (0.72) | FFAR2TP53SMN1; SMN2MAPK10MEN1 | |
| SCHEMBL4394535 | 0.75 | FFAR2 (0.49) | FFAR2KDR | |
| SCHEMBL31282374 | 0.75 | FFAR2 (0.52) | FFAR2KDRCCNE1CDK2 | |
| SCHEMBL23657202 | 0.74 | MAPT (0.57) | FFAR2MEN1KMT2ACCNE1CDK2 | |
| SCHEMBL21533492 | 0.74 | ALDH1A1 (0.59) | ALDH1A1 | |
| SCHEMBL20284274 | 0.73 | SMN1; SMN2 (0.46) | TP53SMN1; SMN2MAPK10MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3853225-B1 | N-(5-(3-(1-((THIAZOL-2-YL)AMINO)-1-OXOPROPAN-2-YL)PHENYL)PYRIDIN-2-YL)ACRYLAMIDE DERIVATIVES AS CDK7 INHIBITORS FOR THE TREATMENT OF CANCER | YUNGJIN PHARMACEUTICAL CO LTD (KR) | 2023-11-29 | — | — | EP | claimed |