Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 9/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 9/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639638 | 0.91 | IDO1 (0.47) | HRH3CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3074242 | 0.88 | HRH3 (0.46) | HRH3CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3062666 | 0.84 | ADRA2A (0.40) | HRH3CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3072215 | 0.83 | HRH3 (0.47) | HRH3CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3068900 | 0.82 | ADRA2A (0.39) | HRH3CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL13089037 | 0.79 | IDO1 (0.37) | IDO1TDO2SLC6A2 | |
| SCHEMBL3055369 | 0.79 | CYP19A1 (0.44) | HRH3CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3064400 | 0.77 | ADRA2A (0.48) | HRH3CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1638482 | 0.75 | CYP19A1 (0.46) | CYP1A2CYP3A4CYP2D6CYP2C19ADRA2A | |
| SCHEMBL3062592 | 0.74 | ADRA2A (0.40) | HRH3CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155715-B1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | ALLERGAN INC (US) | 2013-03-13 | — | — | EP | disclosed |
| US-20100273814-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | SINHA SANTOSH C | 2010-10-28 | — | — | US | disclosed |
| EP-2155715-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | ALLERGAN, INC. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141312-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | ALLERGAN, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273814-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | CYP11B2, TPMT, COXFA4L2 | HRH3 579/4885CYP1A2 290/4885CYP3A4 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.