Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | LDLR | P01130 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | WNT1 | P04628 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30690658 | 0.87 | CSF1R (0.40) | PDGFRACHRM1HRH3HDAC3HDAC1 | |
| SCHEMBL30690679 | 0.87 | PDGFRA (0.40) | PDGFRACHRM1HRH3HDAC3HDAC1 | |
| SCHEMBL30690812 | 0.85 | PDGFRA (0.60) | PDGFRACHRM1HRH3HDAC3HDAC1 | |
| SCHEMBL30690683 | 0.85 | PDGFRA (0.39) | PDGFRACHRM1HRH3HDAC3HDAC1 | |
| SCHEMBL30690781 | 0.85 | PDGFRA (0.39) | PDGFRACHRM1HRH3HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL30690806 | 0.84 | PDGFRA (0.38) | PDGFRACHRM1HRH3HDAC3HDAC1 | |
| SCHEMBL30690760 | 0.83 | CSF1R (0.40) | PDGFRACHRM1HRH3HDAC3HDAC1 | |
| SCHEMBL30690642 | 0.82 | CSF1R (0.41) | PDGFRACHRM1HRH3HDAC3HDAC1 | |
| SCHEMBL30690802 | 0.82 | ABL1 (0.40) | PDGFRACHRM1HRH3HDAC3HDAC1 | |
| SCHEMBL30690774 | 0.82 | GSK3B (0.41) | PDGFRACHRM1HRH3KITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247593-A1 | PYRROLOPYRIDINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |