Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PIR | O00625 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30690788 | 0.82 | PDGFRA (0.40) | ABL1PDGFRACHRM1HRH3KIT | |
| SCHEMBL30690812 | 0.82 | PDGFRA (0.60) | ABL1PDGFRACHRM1HRH3KIT | |
| SCHEMBL30690685 | 0.82 | PDGFRA (0.42) | ABL1PDGFRACHRM1HRH3MAPK14 | |
| SCHEMBL30690774 | 0.81 | GSK3B (0.41) | PDGFRACHRM1HRH3KITGSK3B | |
| SCHEMBL30690679 | 0.81 | PDGFRA (0.40) | ABL1PDGFRACHRM1HRH3KIT | |
| SCHEMBL30690821 | 0.80 | PDGFRA (0.38) | ABL1PDGFRAKITKDRGSK3B | |
| SCHEMBL30690683 | 0.79 | PDGFRA (0.39) | ABL1PDGFRACHRM1HRH3KIT | |
| SCHEMBL30690781 | 0.79 | PDGFRA (0.39) | ABL1PDGFRACHRM1HRH3KIT | |
| Hydrochloric Acid SCHEMBL30690806 | 0.78 | PDGFRA (0.38) | ABL1PDGFRACHRM1HRH3KIT | |
| SCHEMBL27277523 | 0.78 | ABL1 (0.49) | ABL1PDGFRACHRM1HRH3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247593-A1 | PYRROLOPYRIDINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |