Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30690679 | 0.89 | PDGFRA (0.40) | PIM1PIM2MAPTWNT1GSK3B | |
| SCHEMBL30690821 | 0.85 | PDGFRA (0.38) | CHEK1WNT1GSK3BDYRK1AMET | |
| SCHEMBL30690781 | 0.82 | PDGFRA (0.39) | WNT1GSK3BDYRK1AMETCLK2 | |
| SCHEMBL30690645 | 0.81 | IRAK4 (0.35) | PIM1DGAT1 | |
| Hydrochloric Acid SCHEMBL30690806 | 0.81 | PDGFRA (0.38) | WNT1GSK3BDYRK1AMETCLK2 | |
| SCHEMBL30690683 | 0.80 | PDGFRA (0.39) | WNT1GSK3BDYRK1ADGAT1CLK2 | |
| SCHEMBL30690647 | 0.80 | DYRK1A (0.41) | WNT1GSK3BDYRK1ACLK2CLK3 | |
| SCHEMBL20597948 | 0.79 | NPC1 (0.39) | NPC1MAPTDGAT1 | |
| SCHEMBL30690630 | 0.79 | NPC1 (0.39) | NPC1MAPTDGAT1 | |
| SCHEMBL30690760 | 0.79 | CSF1R (0.40) | MAPTWNT1GSK3BDYRK1ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247593-A1 | PYRROLOPYRIDINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |