Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 14/20 | 0.74 |
| ▸ | FAAH | O00519 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | AADAC | P22760 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3069359 | 1.00 | EPHX2 (0.74) | EPHX2FAAHDRD2HTR2ADRD3 | |
| SCHEMBL3079529 | 0.91 | EPHX2 (0.60) | EPHX2FAAHRECQL | |
| SCHEMBL3079526 | 0.91 | EPHX2 (0.60) | EPHX2FAAHRECQL | |
| SCHEMBL14715752 | 0.88 | HTR2A (0.59) | EPHX2DRD2HTR2ADRD3 | |
| SCHEMBL3090256 | 0.88 | HTR2A (0.59) | EPHX2DRD2HTR2ADRD3 | |
| SCHEMBL3074535 | 0.87 | EPHX2 (0.56) | EPHX2FAAHDRD2HTR2ADRD3 | |
| SCHEMBL3074537 | 0.87 | EPHX2 (0.56) | EPHX2FAAHDRD2HTR2ADRD3 | |
| SCHEMBL3182533 | 0.86 | EPHX2 (1.00) | EPHX2FAAHAADAC | |
| SCHEMBL3182544 | 0.86 | EPHX2 (1.00) | EPHX2FAAHAADAC | |
| SCHEMBL27900170 | 0.84 | EPHX2 (0.51) | EPHX2FAAHDRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | disclosed |
| CN-101535258-B | ether derivatives dual modulators of the 5HT2A and D3 receptors | HOFFMANN LA ROCHE | 2012-12-05 | — | — | CN | disclosed |
| US-7795437-B2 | Ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-09-14 | — | — | US | disclosed |
| EP-2079693-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008052899-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | disclosed |
| US-20080103174-A1 | ETHER DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103174-A1 | ETHER DERIVATIVES | GABRE, BDNF, ADH1A | EPHX2 602/4885FAAH 1229/4885DRD2 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.