Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Methylparaben. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.52 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 8/20 | 0.91 |
| ▸ | CA2 | P00918 | 8/20 | 0.91 |
| ▸ | CA12 | O43570 | 5/20 | 0.91 |
| ▸ | CA7 | P43166 | 5/20 | 0.91 |
| ▸ | CA9 | Q16790 | 5/20 | 0.91 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 2/20 | 0.55 |
| ▸ | XDH | P47989 | 1/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylparaben SCHEMBL9387143 | 0.95 | CA1 (0.91) | CA1CA2CA12CA7CA9 | |
| Methylparaben SCHEMBL20597668 | 0.95 | CA1 (0.91) | CA1CA2CA12CA7CA9 | |
| Methylparaben SCHEMBL321534 | 0.95 | CA1 (1.00) | CA1CA2CA12CA7CA9 | |
| Methylparaben SCHEMBL4440 | 0.95 | CA1 (1.00) | CA1CA2CA12CA7CA9 | |
| Methylparaben SCHEMBL8779118 | 0.93 | CA1 (0.95) | CA1CA2CA12CA7CA9 | |
| Methylparaben SCHEMBL475867 | 0.93 | CA1 (0.95) | CA1CA2CA12CA7CA9 | |
| Methylparaben SCHEMBL21274302 | 0.93 | CA1 (0.95) | CA1CA2CA12CA7CA9 | |
| Methylparaben SCHEMBL16029235 | 0.93 | CA1 (0.95) | CA1CA2CA12CA7CA9 | |
| Methylparaben SCHEMBL2810862 | 0.93 | CA1 (0.95) | CA1CA2CA12CA7CA9 | |
| Methylparaben SCHEMBL6315862 | 0.93 | CA1 (0.95) | CA1CA2CA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4302825-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF INAPPETENCE | Elanco Animal Health Incorporated (US) | 2024-01-10 | — | — | EP | claimed |
| EP-0954260-A1 | COMPOSITIONS, METHODS AND DEVICES FOR THE TRANSDERMAL DELIVERY OF DRUGS | Diversified Pharmaceuticals, Inc. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997043989-A1 | COMPOSITIONS, METHODS AND DEVICES FOR THE TRANSDERMAL DELIVERY OF DRUGS | DIVERSIFIED PHARMACEUTICALS, INC. (US) | 1997-11-27 | — | — | WO | claimed |
| EP-4302825-A2 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF INAPPETENCE | Elanco Animal Health Incorporated (US) | 2024-01-10 | — | — | EP | disclosed |
| EP-3524260-B1 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF INAPPETENCE | ELANCO ANIMAL HEALTH INCORPORATED (US) | 2023-09-13 | — | — | EP | disclosed |
| EP-2217201-B1 | COMPOSITION FOR TOPICAL USE TO ACHIEVE A RAPID AND INTENSE LIFTING EFFECT | EXALYA S R L (IT) | 2018-12-19 | — | — | EP | disclosed |
| US-20100261794-A1 | COMPOSITION FOR TOPICAL USE TO ACHIEVE A RAPID AND INTENSE LIFTING EFFECT | DE PAOLI AMBROSI GIANFRANCO | 2010-10-14 | — | — | US | disclosed |
| CN-101854906-A | Topical composition for obtaining a rapidly increasing boost effect | GIANFRANCO DE PAOLI AMBROSI | 2010-10-06 | — | — | CN | disclosed |
| EP-0845977-A1 | CLEAR COSMETIC GEL COMPOSITION | Colgate-Palmolive Company (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1997006777-A1 | CLEAR COSMETIC GEL COMPOSITION | COLGATE-PALMOLIVE COMPANY (US) | 1997-02-27 | — | — | WO | disclosed |