Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25324067 | 0.95 | MGLL (0.41) | MGLLEPHX2KITENPP2ATXN2 | |
| SCHEMBL30700080 | 0.93 | MGLL (0.40) | MGLLEPHX2KIT | |
| SCHEMBL25325570 | 0.81 | MGLL (0.41) | MGLLEPHX2KITENPP2ATXN2 | |
| SCHEMBL25325375 | 0.81 | MGLL (0.44) | MGLLEPHX2 | |
| SCHEMBL30700373 | 0.80 | MGLL (0.43) | MGLLEPHX2 | |
| SCHEMBL31549771 | 0.80 | MGLL (0.37) | MGLLEPHX2ENPP2ATXN2 | |
| SCHEMBL25327554 | 0.78 | MGLL (0.39) | MGLLKIT | |
| SCHEMBL30553269 | 0.78 | MGLL (0.39) | MGLLKIT | |
| SCHEMBL25325303 | 0.78 | MGLL (0.37) | MGLLEPHX2KITENPP2ATXN2 | |
| SCHEMBL30700050 | 0.78 | MGLL (0.41) | MGLLENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |