Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700184 | 0.83 | MGLL (0.37) | EPHX2MGLLSCN9ACHRM4ABL1 | |
| SCHEMBL30700504 | 0.81 | MGLL (0.40) | MGLLABL1 | |
| SCHEMBL30700080 | 0.81 | MGLL (0.40) | EPHX2MGLL | |
| SCHEMBL31549771 | 0.81 | MGLL (0.37) | EPHX2MGLLENPP2ATXN2BTK | |
| SCHEMBL30775825 | 0.81 | MGLL (0.50) | MGLL | |
| SCHEMBL30700479 | 0.80 | MGLL (0.38) | MGLLABL1 | |
| SCHEMBL25325570 | 0.79 | MGLL (0.41) | EPHX2MGLLENPP2ATXN2 | |
| SCHEMBL30700434 | 0.79 | MGLL (0.40) | MGLLABL1 | |
| SCHEMBL30700104 | 0.79 | KDM4E (0.42) | MGLLSCN9AHSD11B1ABL1 | |
| SCHEMBL30700534 | 0.78 | MGLL (0.39) | EPHX2MGLLCHRM4ABL1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |