Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700057 | 0.82 | KMT2A (0.47) | KMT2AMEN1L3MBTL1ALDH1A1POLB | |
| SCHEMBL30700774 | 0.78 | AKR1C3 (0.42) | KMT2AMEN1AKR1C3L3MBTL1ALDH1A1 | |
| SCHEMBL30700308 | 0.77 | EPHX2 (0.42) | KMT2AMEN1AKR1C3HSD11B1TRPV4 | |
| SCHEMBL30700189 | 0.77 | EPHX2 (0.42) | KMT2AMEN1AKR1C3HSD11B1TRPV4 | |
| SCHEMBL30720227 | 0.75 | MGLL (0.57) | KMT2AMEN1AKR1C3L3MBTL1ALDH1A1 | |
| SCHEMBL25325494 | 0.75 | KMT2A (0.43) | KMT2AMEN1AKR1C3L3MBTL1ALDH1A1 | |
| SCHEMBL30700279 | 0.71 | ERAP1 (0.36) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL31307984 | 0.70 | KMT2A (0.61) | KMT2AMEN1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL25325553 | 0.70 | KMT2A (0.39) | KMT2AMEN1AKR1C3ALDH1A1POLB | |
| SCHEMBL30700443 | 0.67 | KDM5A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |