Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700308 | 1.00 | EPHX2 (0.42) | EPHX2TRPV4SPRCACNA1BRBP4 | |
| SCHEMBL30700279 | 0.85 | ERAP1 (0.36) | CACNA1BMEN1KMT2A | |
| SCHEMBL30700677 | 0.80 | MGLL (0.40) | EPHX2RBP4 | |
| SCHEMBL30700527 | 0.78 | EPHX2 (0.43) | EPHX2TRPV4SPRCACNA1BRBP4 | |
| SCHEMBL30700181 | 0.78 | EPHX2 (0.43) | EPHX2TRPV4SPRCACNA1BRBP4 | |
| SCHEMBL30699985 | 0.78 | EPHX2 (0.43) | EPHX2TRPV4SPRCACNA1BRBP4 | |
| SCHEMBL30700426 | 0.77 | KMT2A (0.45) | TRPV4HSD11B1AKR1C3MEN1KMT2A | |
| SCHEMBL27154085 | 0.75 | MGLL (0.55) | EPHX2TRPV4SPRCACNA1BRBP4 | |
| SCHEMBL23850535 | 0.75 | MGLL (0.51) | — | |
| SCHEMBL32685335 | 0.75 | MGLL (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |