Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700456 | 0.92 | APLNR (0.39) | HSD11B1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL30700296 | 0.88 | MGLL (0.36) | HSD11B1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL30700024 | 0.84 | CA12 (0.39) | HSD11B1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL30700496 | 0.84 | PRMT5 (0.35) | HSD11B1RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL30700264 | 0.81 | MGLL (0.43) | HSD11B1TP53ALDH1A1MGLL | |
| SCHEMBL30700661 | 0.81 | MGLL (0.34) | HSD11B1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL30700311 | 0.78 | PARP10 (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1MGLL | |
| SCHEMBL30700040 | 0.78 | PARP10 (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1MGLL | |
| SCHEMBL30700767 | 0.78 | MGLL (0.38) | HSD11B1SMN1; SMN2MGLL | |
| SCHEMBL27290972 | 0.77 | MGLL (0.42) | HSD11B1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |