Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.40 |
| ▸ | STS | P08842 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31308789 | 1.00 | GPR119 (0.42) | GPR119TGFBR1STSJAK2JAK1 | |
| SCHEMBL30700723 | 1.00 | GPR119 (0.42) | GPR119TGFBR1STSJAK2JAK1 | |
| SCHEMBL31308665 | 1.00 | GPR119 (0.42) | GPR119TGFBR1STSJAK2JAK1 | |
| SCHEMBL25254840 | 0.93 | GPR119 (0.40) | GPR119TGFBR1STSJAK2JAK1 | |
| SCHEMBL29497018 | 0.93 | GPR119 (0.40) | GPR119TGFBR1STSJAK2JAK1 | |
| SCHEMBL30700689 | 0.87 | RORC (0.36) | RORC | |
| SCHEMBL29427074 | 0.84 | GPR119 (0.46) | GPR119STS | |
| SCHEMBL25411376 | 0.84 | GPR119 (0.46) | GPR119STS | |
| SCHEMBL30011751 | 0.83 | GPR119 (0.39) | GPR119TGFBR1STSSFRP1RORC | |
| SCHEMBL27145110 | 0.83 | GPR119 (0.39) | GPR119TGFBR1STSSFRP1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |