Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 9/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25324153 | 0.82 | CACNA1B (0.40) | CACNA1BNR1I2SLC6A9CYP3A4TYK2 | |
| SCHEMBL30700390 | 0.79 | GPBAR1 (0.36) | MGLL | |
| SCHEMBL30699868 | 0.78 | MGLL (0.34) | PROKR1MGLL | |
| SCHEMBL30700020 | 0.77 | MGLL (0.33) | MGLL | |
| SCHEMBL30700668 | 0.77 | MGLL (0.36) | MGLL | |
| SCHEMBL30700204 | 0.77 | MGLL (0.39) | TYK2JAK2JAK1MGLL | |
| SCHEMBL30700223 | 0.77 | MGLL (0.39) | TYK2JAK2JAK1MGLL | |
| SCHEMBL30700444 | 0.76 | MGLL (0.41) | CYP3A4TYK2JAK2JAK1MGLL | |
| SCHEMBL31308016 | 0.75 | ENPP2 (0.41) | CYP3A4TYK2JAK2JAK1MGLL | |
| SCHEMBL31307999 | 0.75 | ENPP2 (0.41) | CYP3A4TYK2JAK2JAK1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |