Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 12/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.58 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.58 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.58 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.58 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.58 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.58 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.58 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.58 |
| ▸ | PRKX | P51817 | 1/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007383 | 0.88 | ROCK1 (0.53) | ROCK1ROCK2PRKCDPRKACAPRKG1 | |
| SCHEMBL4007388 | 0.88 | ROCK1 (0.53) | ROCK1ROCK2PRKCDPRKACAPRKG1 | |
| SCHEMBL12851367 | 0.87 | ROCK1 (0.61) | ROCK1ROCK2PRKCDPRKACAPRKG1 | |
| SCHEMBL3224404 | 0.85 | ROCK1 (0.58) | ROCK1ROCK2PRKCDPRKACAPRKG1 | |
| SCHEMBL12851337 | 0.83 | ROCK1 (0.61) | ROCK1ROCK2PRKCDPRKACAPRKG1 | |
| SCHEMBL28677741 | 0.83 | KDM4E (0.51) | GPR119 | |
| SCHEMBL3226359 | 0.83 | ROCK1 (0.55) | ROCK1ROCK2PRKCDPRKACAPRKG1 | |
| SCHEMBL31482744 | 0.83 | ROCK1 (0.47) | ROCK1ROCK2PRKCDPRKACAPRKG1 | |
| SCHEMBL3226341 | 0.83 | ROCK1 (0.55) | ROCK1ROCK2PRKCDPRKACAPRKG1 | |
| SCHEMBL2332126 | 0.82 | GPR119 (0.55) | GPR119ALKCHEK2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612382-B2 | Process for preparing 6-substituted-1-(2H)-isoquinolinones and intermediate compound | VALO HEALTH INC. (US) | 2026-04-28 | — | — | US | disclosed |
| US-20250296923-A1 | PROCESS FOR PREPARING 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES AND INTERMEDIATE COMPOUND | VALO HEALTH, INC. (US) | 2025-09-25 | — | — | US | disclosed |
| US-20240287031-A1 | PROCESS FOR PREPARING 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES AND INTERMEDIATE COMPOUND | VALO HEALTH, INC. (US) | 2024-08-29 | — | — | US | disclosed |
| US-20240287030-A1 | PROCESS FOR PREPARING 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES AND INTERMEDIATE COMPOUND | VALO HEALTH, INC. (US) | 2024-08-29 | — | — | US | disclosed |
| EP-4402129-A1 | <SMALLCAPS/>? ? ?H? ? ? ? ?PROCESS FOR PREPARING 6-SUBSTITUTED-1-(2)-ISOQUINOLINONES AND INTERMEDIATE COMPOUND | Valo Health, Inc. (US) | 2024-07-24 | — | — | EP | disclosed |
| WO-2024030854-A1 | PROCESS FOR PREPARING 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES AND INTERMEDIATE COMPOUND | VALO HEALTH, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287031-A1 | PROCESS FOR PREPARING 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES AND INTERMEDIATE COMPOUND | ROCK1, ROCK2, CIT | ROCK1 1/4885ROCK2 2/4885PRKCD 302/4885 |
| US-20250296923-A1 | PROCESS FOR PREPARING 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES AND INTERMEDIATE COMPOUND | ROCK1, ROCK2, CIT | ROCK1 1/4885ROCK2 2/4885PRKCD 302/4885 |
| US-12612382-B2 | Process for preparing 6-substituted-1-(2H)-isoquinolinones and intermediate compound | ROCK1, RHOA, ABL1 | ROCK1 1/4885ROCK2 7/4885PRKCD 379/4885 |
| US-20240287030-A1 | PROCESS FOR PREPARING 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES AND INTERMEDIATE COMPOUND | ROCK1, ROCK2, CIT | ROCK1 1/4885ROCK2 2/4885PRKCD 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.