Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 3/20 | 0.48 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | USP1 | O94782 | 2/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.36 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.36 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30701934 | 0.82 | INPPL1 (0.44) | INPPL1MAP4K3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30701904 | 0.80 | MAPT (0.47) | — | |
| SCHEMBL30701925 | 0.74 | INPPL1 (0.82) | INPPL1MAP4K3PAK4PAK1 | |
| Hydrochloric Acid SCHEMBL30701912 | 0.74 | INPPL1 (0.81) | INPPL1MAP4K3PAK4PAK1 | |
| SCHEMBL30701936 | 0.70 | INPPL1 (0.58) | INPPL1MAP4K3SRCPAK4PAK1 | |
| SCHEMBL20134926 | 0.65 | JAK2 (0.49) | USP1 | |
| SCHEMBL31465935 | 0.64 | P2RY14 (0.46) | USP1 | |
| Hydrochloric Acid SCHEMBL30701910 | 0.64 | INPPL1 (0.98) | INPPL1MAP4K3PAK4PAK1 | |
| SCHEMBL8696039 | 0.64 | HTR6 (0.42) | MAP4K3SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL26151162 | 0.63 | INPPL1 (0.74) | INPPL1MAP4K3PAK4PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554936-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | The Trustees of Indiana University (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015759-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-18 | — | — | WO | disclosed |