Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 1/20 | 0.56 |
| ▸ | MAP4K3 | Q8IVH8 | 3/20 | 0.48 |
| ▸ | MET | P08581 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30701933 | 0.90 | INPPL1 (0.57) | INPPL1MAP4K3METFAAHPAK1 | |
| SCHEMBL30701916 | 0.88 | INPPL1 (0.57) | INPPL1MAP4K3METNPC1RAB9A | |
| SCHEMBL30701915 | 0.88 | INPPL1 (0.57) | INPPL1MAP4K3METFAAH | |
| SCHEMBL30701925 | 0.81 | INPPL1 (0.82) | INPPL1MAP4K3METPAK1PAK4 | |
| SCHEMBL30701923 | 0.80 | MET (0.54) | INPPL1MAP4K3MET | |
| Hydrochloric Acid SCHEMBL30701912 | 0.80 | INPPL1 (0.81) | INPPL1MAP4K3METPAK1PAK4 | |
| SCHEMBL30701935 | 0.80 | INPPL1 (0.69) | INPPL1MET | |
| SCHEMBL30701908 | 0.79 | MET (0.54) | INPPL1MAP4K3MET | |
| SCHEMBL30701917 | 0.78 | INPPL1 (0.59) | INPPL1MAP4K3METPAK1PAK4 | |
| SCHEMBL30701926 | 0.77 | INPPL1 (0.52) | INPPL1MAP4K3METSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554936-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | The Trustees of Indiana University (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015759-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-18 | — | — | WO | disclosed |