Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.54 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.50 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.48 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | LIPC | P11150 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30701915 | 0.93 | INPPL1 (0.57) | METMAP4K3TNK2INPPL1KEAP1 | |
| SCHEMBL30701935 | 0.85 | INPPL1 (0.69) | METTNK2INPPL1FGFR1FGFR2 | |
| SCHEMBL30701908 | 0.84 | MET (0.54) | METMAP4K3TNK2INPPL1FGFR1 | |
| SCHEMBL30701933 | 0.83 | INPPL1 (0.57) | METMAP4K3INPPL1 | |
| SCHEMBL28806344 | 0.81 | MET (0.53) | METTNK2FGFR1FGFR2FGFR4 | |
| SCHEMBL30701926 | 0.81 | INPPL1 (0.52) | METMAP4K3TNK2INPPL1FGFR1 | |
| SCHEMBL17310184 | 0.81 | ALK (0.69) | METMAP4K3TNK2FGFR1FGFR2 | |
| SCHEMBL30701918 | 0.80 | INPPL1 (0.56) | METMAP4K3INPPL1 | |
| SCHEMBL1653749 | 0.80 | TNK2 (0.56) | METTNK2FGFR1FGFR2FGFR4 | |
| SCHEMBL28762753 | 0.79 | MAP4K3 (0.52) | METMAP4K3TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554936-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | The Trustees of Indiana University (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015759-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-18 | — | — | WO | disclosed |