Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 2/20 | 0.70 |
| ▸ | MAP4K3 | Q8IVH8 | 12/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.56 |
| ▸ | MET | P08581 | 3/20 | 0.50 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30701925 | 0.88 | INPPL1 (0.82) | INPPL1MAP4K3ALKMETPAK1 | |
| Hydrochloric Acid SCHEMBL30701912 | 0.87 | INPPL1 (0.81) | INPPL1MAP4K3ALKMETPAK1 | |
| SCHEMBL30701908 | 0.82 | MET (0.54) | INPPL1MAP4K3MET | |
| Hydrochloric Acid SCHEMBL30701910 | 0.82 | INPPL1 (0.98) | INPPL1MAP4K3ALKMETPAK1 | |
| SCHEMBL26151162 | 0.81 | INPPL1 (0.74) | INPPL1MAP4K3ALKMETPAK1 | |
| SCHEMBL30701905 | 0.80 | INPPL1 (0.75) | INPPL1MAP4K3ALKMETPAK1 | |
| SCHEMBL16302890 | 0.78 | MET (0.57) | MAP4K3ALKMETPAK1 | |
| SCHEMBL26151168 | 0.76 | MAP4K3 (0.70) | INPPL1MAP4K3ALKMETPAK1 | |
| SCHEMBL30701917 | 0.75 | INPPL1 (0.59) | INPPL1MAP4K3ALKMETPAK1 | |
| SCHEMBL13743614 | 0.75 | CHRNB2 (0.57) | INPPL1MAP4K3ALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554936-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | The Trustees of Indiana University (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015759-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-18 | — | — | WO | disclosed |