Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTH | P32929 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26932725 | 1.00 | ALDH1A1 (0.46) | ALDH1A1KDM4ETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL26932631 | 1.00 | ALDH1A1 (0.46) | ALDH1A1KDM4ETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL17305466 | 0.81 | HTR2A (0.34) | ALDH1A1KDM4EL3MBTL1NPC1MEN1 | |
| SCHEMBL26932950 | 0.79 | RAB9A (0.40) | ALDH1A1KDM4ERAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL26932629 | 0.79 | RAB9A (0.40) | ALDH1A1KDM4ERAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL30704195 | 0.77 | MAPT (0.51) | ALDH1A1KDM4ERAB9AMEN1KMT2A | |
| SCHEMBL1914364 | 0.76 | KDM4E (0.42) | ALDH1A1KDM4ETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL16737458 | 0.76 | KDM4E (0.42) | ALDH1A1KDM4ETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL1914087 | 0.73 | KDM4E (0.50) | ALDH1A1KDM4ETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL1914082 | 0.73 | KDM4E (0.50) | ALDH1A1KDM4ETSHRRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4536668-A1 | PYRIDO[4,3-D]PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS | Bristol-Myers Squibb Company (US) | 2025-04-16 | — | — | EP | disclosed |
| CN-119630676-A | Pyrido [4,3-D ] pyrimidine derivatives as KRAS inhibitors | 百时美施贵宝公司 | 2025-03-14 | — | — | CN | disclosed |
| WO-2023240188-A1 | PYRIDO[4,3-D]PYRIMIDINE DERIVATIVES AS KRAS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-12-14 | — | — | WO | disclosed |