Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30710370 | 0.88 | MEN1 (0.65) | KMT2AMEN1MAPKAPK2KDM1A | |
| SCHEMBL27276907 | 0.80 | MEN1 (0.65) | KMT2AMEN1CHRNB2CHRNA4CA1 | |
| SCHEMBL30734291 | 0.80 | MEN1 (0.65) | KMT2AMEN1CHRNB2CHRNA4CA1 | |
| SCHEMBL30710343 | 0.80 | CHRNB2 (0.44) | KMT2AMEN1TSHRKIF11GRIN2B | |
| SCHEMBL30710485 | 0.80 | CHRNB2 (0.44) | KMT2AMEN1TSHRKIF11GRIN2B | |
| SCHEMBL29557450 | 0.76 | MEN1 (0.41) | KMT2AMEN1TSHRKIF11TRPA1 | |
| SCHEMBL17971658 | 0.76 | MEN1 (0.41) | KMT2AMEN1TSHRKIF11TRPA1 | |
| SCHEMBL28697343 | 0.76 | MEN1 (0.41) | KMT2AMEN1TSHRKIF11TRPA1 | |
| SCHEMBL22784451 | 0.76 | MEN1 (0.65) | KMT2AMEN1MAPKAPK2CA1CA2 | |
| SCHEMBL29560484 | 0.76 | MEN1 (0.65) | KMT2AMEN1MAPKAPK2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250439-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |