Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | KDM1A | O60341 | 5/20 | 0.53 |
| ▸ | PRCP | P42785 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27276907 | 1.00 | MEN1 (0.65) | MEN1KMT2AKDM1APRCPGAA | |
| SCHEMBL30710370 | 0.90 | MEN1 (0.65) | MEN1KMT2AKDM1APRCPGAA | |
| SCHEMBL27969852 | 0.82 | MAPKAPK2 (0.57) | MEN1KMT2ACA1CA2CA7 | |
| Toluene SCHEMBL28038158 | 0.81 | MEN1 (0.49) | MEN1KMT2ADRD2CHRNB2CHRNA4 | |
| SCHEMBL3818749 | 0.81 | MEN1 (0.56) | MEN1KMT2ADRD2CHRNB2CHRNA4 | |
| SCHEMBL30710364 | 0.80 | KMT2A (0.52) | MEN1KMT2AKDM1ACA1CA2 | |
| SCHEMBL29560484 | 0.78 | MEN1 (0.65) | MEN1KMT2AKDM1APRCPGID4 | |
| SCHEMBL22784451 | 0.78 | MEN1 (0.65) | MEN1KMT2AKDM1APRCPGID4 | |
| SCHEMBL30710343 | 0.77 | CHRNB2 (0.44) | MEN1KMT2AGAACA1CA2 | |
| SCHEMBL30710485 | 0.77 | CHRNB2 (0.44) | MEN1KMT2AGAACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250399-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |