Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | AGER | Q15109 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29201831 | 1.00 | KDM4E (0.46) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL2749868 | 0.88 | KDM4E (0.49) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL2131018 | 0.82 | KDM4E (0.44) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL258368 | 0.79 | KDM4E (0.53) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 | |
| Hydrochloric Acid SCHEMBL5739430 | 0.78 | KDM4E (0.52) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL22922739 | 0.78 | KDM4E (0.52) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL11284703 | 0.77 | NAPRT (0.56) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL9858538 | 0.77 | KDM4E (0.55) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL4005286 | 0.76 | GABRP (0.56) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL2749775 | 0.76 | KDM4E (0.50) | KDM4ETDP1ALDH1A1L3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117637186-B | Method for screening and preparing active molecule group in tripterygium plants and application thereof | 重庆市中药研究院 | 2024-10-22 | — | — | CN | claimed |
| CN-117338831-B | Tripterygium wilfordii hook extract and preparation method and application thereof | 重庆市中药研究院 | 2024-12-03 | — | — | CN | disclosed |
| CN-117637186-B | Method for screening and preparing active molecule group in tripterygium plants and application thereof | 重庆市中药研究院 | 2024-10-22 | — | — | CN | disclosed |
| CN-117637186-A | Method for screening and preparing active molecule group in tripterygium plants and application thereof | 重庆市中药研究院 | 2024-03-01 | — | — | CN | disclosed |
| CN-117338831-A | Low-toxicity tripterygium wilfordii extract and preparation method and application thereof | 重庆市中药研究院 | 2024-01-05 | — | — | CN | disclosed |