SCHEMBL30717569

SCHEMBL30717569

CC(C)(C)OC(=O)N1CC2CCC(C1)N2c1nc2c(s1)CN(C(=O)C(C)(O)C1CCCC1)CC2

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GRAMD1A Q96CP6 1/20 0.39
GCK P35557 9/20 0.38
ADORA1 P30542 2/20 0.35
SPR P35270 1/20 0.33
SCN4A P35499 1/20 0.33
F10 P00742 2/20 0.33
GPR119 Q8TDV5 1/20 0.33
OPRM1 P35372 1/20 0.33
OPRD1 P41143 1/20 0.33
OPRK1 P41145 1/20 0.33
OGFRL1 Q5TC84 1/20 0.33
GRM5 P41594 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30717613 0.87 GRAMD1A (0.41) GRAMD1AGCKADORA1SPRSCN4A
SCHEMBL30717629 0.85 GCK (0.43) GRAMD1AGCKADORA1SCN4AF10
SCHEMBL30717513 0.84 GRM5 (0.35) GRM5
SCHEMBL30717587 0.81 GRM5 (0.40) GRAMD1AGCKADORA1F10GRM5
SCHEMBL30717601 0.81 GRAMD1A (0.38) GRAMD1AGCKADORA1SPRSCN4A
SCHEMBL30717657 0.80 ADORA1 (0.35) GRAMD1AGCKADORA1SPRSCN4A
SCHEMBL30717590 0.79 GRAMD1A (0.39) GRAMD1AGCKADORA1SPRSCN4A
SCHEMBL30717693 0.78 GCK (0.46) GRAMD1AGCKGPR119MAPT
SCHEMBL30717557 0.76 GRM5 (0.35) GRM5
SCHEMBL30717608 0.75 DDB1 (0.37) GRAMD1ASPRSCN4AGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4572762-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS Mironid Limited (GB) 2025-06-25 EP disclosed
WO-2024038128-A1 COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS MIRONID LIMITED (GB) 2024-02-22 WO disclosed