Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.36 |
| ▸ | MTOR | P42345 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29115840 | 1.00 | MAPKAPK2 (0.41) | MAPKAPK2SLC22A12MAP4K4CSNK1G2CLK4 | |
| SCHEMBL30718176 | 1.00 | MAPKAPK2 (0.41) | MAPKAPK2SLC22A12MAP4K4CSNK1G2CLK4 | |
| SCHEMBL27029442 | 0.81 | ACHE (0.55) | PIK3CAACHE | |
| SCHEMBL30718211 | 0.81 | ACHE (0.55) | PIK3CAACHE | |
| SCHEMBL27029459 | 0.78 | GPR119 (0.44) | HDAC8PIK3CAMTOR | |
| SCHEMBL30718161 | 0.78 | GPR119 (0.44) | HDAC8PIK3CAMTOR | |
| SCHEMBL1857851 | 0.74 | PIK3CA (0.42) | MAPKAPK2SLC22A12MAP4K4CSNK1G2CLK4 | |
| SCHEMBL29115939 | 0.71 | BCHE (0.48) | HDAC8 | |
| SCHEMBL29931621 | 0.71 | BCHE (0.48) | HDAC8 | |
| SCHEMBL27029490 | 0.69 | CKS1B (0.47) | PIK3CAMTORACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157284-A | CTLA-4 small molecule degradation agent and application thereof | 苏州国匡医药科技有限公司 | 2023-12-01 | — | — | CN | disclosed |