Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.41 |
| ▸ | JAK3 | P52333 | 11/20 | 0.41 |
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30718309 | 1.00 | JAK1 (0.41) | JAK1JAK3JAK2CHEK1KCNH2 | |
| SCHEMBL30718296 | 0.91 | JAK1 (0.41) | JAK1JAK3JAK2CHEK1KCNH2 | |
| SCHEMBL30718299 | 0.79 | JAK1 (0.40) | JAK1JAK3JAK2 | |
| SCHEMBL29276172 | 0.74 | NOS1 (0.36) | CHEK1KCNH2NOS3NOS1NOS2 | |
| SCHEMBL30214761 | 0.74 | NOS1 (0.36) | CHEK1KCNH2NOS3NOS1NOS2 | |
| SCHEMBL14615713 | 0.73 | JAK3 (0.76) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL20183452 | 0.73 | JAK3 (0.76) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26647685 | 0.70 | JAK2 (0.42) | JAK2CHEK1KCNH2NOS3NOS1 | |
| SCHEMBL26647678 | 0.70 | JAK2 (0.42) | JAK2CHEK1KCNH2NOS3NOS1 | |
| SCHEMBL30718319 | 0.70 | JAK1 (0.40) | JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006559-A1 | MODULATORS OF NLRP3 INFLAMMASOME AND RELATED PRODUCTS AND METHODS | Neumora Therapeutics, Inc. (US) | 2024-01-04 | — | — | WO | disclosed |