Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23496922 | 1.00 | HPGD (0.68) | HPGDSMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL7073698 | 0.86 | HPGD (0.64) | HPGDSMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL30719608 | 0.86 | HPGD (0.64) | HPGDSMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL30719633 | 0.83 | TBXAS1 (0.56) | HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23496973 | 0.83 | TBXAS1 (0.56) | HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1376771 | 0.81 | HPGD (0.71) | HPGDSMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL8864677 | 0.79 | HPGD (0.70) | HPGDSMN1; SMN2HTTALDH1A1NPSR1 | |
| SCHEMBL8864710 | 0.77 | HPGD (0.60) | HPGDSMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL8224982 | 0.77 | HPGD (0.74) | HPGDSMN1; SMN2HTTLMNAALDH1A1 | |
| SCHEMBL21904798 | 0.75 | SMN1; SMN2 (0.82) | HPGDSMN1; SMN2HTTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-117586191-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-111542515-B | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2023-12-05 | — | — | CN | disclosed |