Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.48 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.48 |
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP1 | P63208 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.46 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260665 | 1.00 | GPR119 (0.48) | GPR119TRPC6CKS1BSKP1SKP2 | |
| SCHEMBL30720125 | 0.89 | MEN1 (0.48) | GPR119TRPC6CKS1BSKP1SKP2 | |
| SCHEMBL31173963 | 0.85 | ALK (0.48) | GPR119CKS1BSKP1SKP2MEN1 | |
| SCHEMBL21045603 | 0.85 | TRPC6 (0.56) | GPR119TRPC6CKS1BSKP1SKP2 | |
| SCHEMBL30419595 | 0.85 | TRPC6 (0.56) | GPR119TRPC6CKS1BSKP1SKP2 | |
| SCHEMBL103379 | 0.81 | CKS1B (0.47) | GPR119CKS1BSKP1SKP2MEN1 | |
| SCHEMBL21045914 | 0.81 | SMPD3 (0.48) | GPR119CKS1BSKP1SKP2MEN1 | |
| SCHEMBL29911202 | 0.81 | SMPD3 (0.48) | GPR119CKS1BSKP1SKP2MEN1 | |
| SCHEMBL25189508 | 0.79 | CKS1B (0.49) | GPR119TRPC6CKS1BSKP1SKP2 | |
| SCHEMBL16334051 | 0.79 | CKS1B (0.51) | GPR119CKS1BSKP1SKP2TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554948-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Regents of the University of Michigan (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015409-A1 | CHROMAN DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |
| WO-2024015406-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |