Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 2/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30720232 | 0.83 | OPRL1 (0.31) | OPRL1 | |
| SCHEMBL30720264 | 0.83 | HRH3 (0.43) | HDAC4HRH3TRPV4TRPM8DGAT1 | |
| SCHEMBL27149307 | 0.83 | HRH3 (0.43) | HDAC4HRH3TRPV4TRPM8DGAT1 | |
| SCHEMBL27140022 | 0.82 | HDAC4 (0.45) | HDAC4HRH3TRPV4TRPM8DGAT1 | |
| SCHEMBL27196770 | 0.81 | HRH3 (0.43) | HDAC4HRH3TRPV4TRPM8PSEN1 | |
| SCHEMBL31307974 | 0.81 | LIPE (0.44) | — | |
| SCHEMBL31308061 | 0.80 | HTR2C (0.41) | KDM1AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL27196872 | 0.80 | HRH3 (0.42) | HDAC4HRH3TRPV4TRPM8PSEN1 | |
| SCHEMBL31307978 | 0.78 | LMNA (0.39) | — | |
| SCHEMBL31308040 | 0.78 | KDM1A (0.39) | TRPV4KDM1AMAOAMAOBOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295726-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2023-12-26 | — | — | CN | claimed |
| US-20240199587-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2024-06-20 | — | — | US | disclosed |
| CN-117295726-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2023-12-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240199587-A1 | HETEROCYCLIC COMPOUNDS | CYP1B1, CYP1A1, CYP4B1 | HDAC4 1611/4885HRH3 1117/4885TRPV4 3928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.